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Medical University - Varna
Prof. Dr. Paraskev Stoyanov

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Assoc.prof. Kameliya Zhechkova Bratoeva

​
Medical University of Varna "Prof. d-r Paraskev Stoyanov", Bulgaria

Катедра: Department of Physiology and pathophysiology
 УС:
 Е-поща: kamelia.bratoeva@mu-varna.bg
Телефон: +359 52 6726 36

 

Биография

Assoc.prof. Kameliya Bratoeva,MD, PhD is a Head of the Department of Pathophysiology at the Department of Physiology and Pathophysiology of the Medical University "Prof. Dr. Paraskev Stoyanov" since 2020. 

Prof. Bratoeva was born in Varna. In 2000, she received her medical degree from the Medical University of Varna. She began her career in the same year as a resident physician in the internal medicine department of the Provadia-based "Tsaritsa Ioanna" Hospital. She served as the primary prehospital care chief expert at the National Health Insurance Fund Varna from 2004 to 2006.

She was hired as an assistant at the Department of Pathophysiology in 2007 following a standard competition. She obtained two medical specialties: pathophysiology in 2012 and social medicine and health management in 2008.
"Mechanism of hepatocyte survival in an experimental model of non-alcoholic fatty liver and antioxidant intake" was the subject of a dissertation that was defended in 2016 in the field of pathophysiology.

Prof. Bratoeva was qualified as an associate professor in 2018, with a habilitation thesis (monograph) on the topic "Damage in metabolic syndrome and non-alcoholic fatty liver disease. General pathophysiological mechanisms and connections". He participated in the implementation of more than 10 scientific projects funded by the Ministry of Education and Science and the Science Fund of MU-Varna, in the following thematic areas: Experimental studies in metabolic syndrome and non-alcoholic fatty liver disease; Biomarkers of endothelial dysfunction in an experimental model of metabolic syndrome; Vascular biology; Biomarkers of cell death in solid tumors; Study of the biological activity and functional properties of Black Sea bivalve tissue as a resource for natural nutraceuticals; 3D bioprinting of tissues for research purposes. "Study of SDF-1α induced activity of endothelial progenitor cells in endothelial dysfunction in an experimental model of obesity", funded by the Science Fund of MU-Varna; project of "Medical University - Varna: Enhancing translational achievements in medicine (MUVE-TEAM)", scientific group RenEVA "Renal epithelial and vascular aging"; and scientific group NutriLect "Nutrition, dietetics and neurodevelopment.

 She was awarded by the competition "Science and Youth" - 2013, "Asclepius" for a presentation on the topic "Oxidative stress and mechanism of hepatocyte survival in fructose-induced hepatic steatosis".

Prof. Bratoeva is the supervisor of six pathophysiology specialists and PhD students.
She is an article reviewer for Cureus: Journal of Medical Science, Metabolic Syndrome and Related Disorders, and Journal of Pharmacy and Pharmacology.

Prof. Bratoeva provides lectures and exercises in pathophysiology for specialties - medicine, dentistry, Bulgarian and English language training, pharmacy, nursing, midwifery and kinesitherapy. She is the co-author of 3 study guides. She has over 50 publications and has presented more than 30 reports at national and international scientific forums and scientific congresses.

Main scientific interests: metabolic syndrome, oxidative stress, vascular biology, biomarkers of cellular damage, neogenesis and death, 3D printing.

Member of Bulgarian Association Of Pathophysiology; Bulgarian Medical Association

Публикации

https://scholar.google.bg/citations?user=Q2LgLy8AAAAJ&hl=bg

https://repository.mu-varna.bg/handle/nls/183​


Selected scientific publications

  1. Bratoeva K, Nikolova S, Merdzhanova A, Stoyanov G, Dimitrova E, Kashlov J, Conev N,  Radanova M. Association between serum ck-18 levels and the degree of liver damage in fructose-induced metabolic syndrome. Journal of Metabolic Syndrome and Related Disorders, 2018 6(7): 350-357. ISSN: 1557-8518
  2. Bratoeva K, Mariya Radanova, Albena Merdzhanova, Ivan Donev.Protective Role of S-Adenosylmethionine Against Fructose-Induced Oxidative Damage in Obesity. Journal of Mind and Medical Sciences. 2017; 4(2): 163-171. ISSN: 2392-7674
  3. Bratoeva K, Stoyanow S. G, Merdzhanova A., Radanova. Manifestations of Renal Impairment in Fructose-induced Metabolic Syndrome. M. CUREUS, 2017;9(11):e1826. ISSN 2168-8184.
  4. G. Bekyarova, M. Tzaneva, K. Bratoeva, I. Kotzev.Heme-oxygenase-1 upregulated by s-adenosylmethionine. potential protection against non-alcoholic fatty liver induced by high fructose diet. FARMACIA. 2017; 65 (2), 262-267 .
  5. Bratoeva K, Bekyarova G. Irina Ivanova, Andrei Kotzev, Minka Hristova at al. 4-Hydroxynonenal (HNE) and hepatic injury related to chronic oxidative stress. Biotechnology & Biotechnological Equipment 2019, VOL. 33, NO. 1, 1544–1552
  6. Veselina Panayotova, Albena Merdzhanova,Diana A. Dobreva, Kameliya Bratoeva, Lubomir Makedonski. Nutritional composition, bioactive compounds and health-beneficial properties of black sea shellfish J of IMAB. 2020 Jul-Sep;26(3)
  7. K. Bratoeva, M. Radanova, A. Merdzhanova.Еffect of аllopurinol on oxidative stress in obesity and liver content of free fatty acids.J. BioSci. Biotechnol. 2015, SE/ONLINE: 91-96.ISSN: 1314-6446
  8. Bratoeva K, Bekyarova G, Kiselova Y, Radanova M, Ivanova D. Мetabolic changes in experimental model of  metabolic syndrom- induced by high- fructose diet in rats. Scripta Scientifica Medica, 2010;42 (4), 233-235.
  9. Bekyarova G., Bratoeva K, Bekyarov N.Uric аcid аnd vascular disorders in metabolic syndrome.Cardiovascular Diseases 2013,44(1),40-44.ISSN 0204-6865
  10. George S. Stoyanov, Ina Kobakova, Lyuben Stoev, Hristo Popov, Savi R. Shishkov, Kameliya Bratoeva. Histological Changes in Severe Diabetic Fetopathy: An Autopsy Case Report. Cureus. 2019/3; 11 (3) e4199.
  11. Ivanova, N. A., Trapani, A., Franco, C. D., Mandracchia, D., Trapani, G., Franchini, C., Bratoeva K et al. (2019). In vitro and ex vivo studies on diltiazem hydrochloride-loaded microsponges in rectal gels for chronic anal fissures treatment. Int. J. Pharm. 25557, 53–65.
  12. E. Dimitrova, B. Chaushev, N. Conev, K. Bratoeva et al. Role of the pretreatment 18F-fluorodeoxyglucose positron emission tomography maximal standardized uptake value in predicting outcomes of colon liver metastasesand that value's association with Beclin-1 expression. BioScience Trends Vol. 11 (2017) No. 2 p. 221-228,
  13. Assia Konsoulova, Ivan Donev, Nikolay Conev, Sonya Draganova, Nadezhda Petrova, Eleonora Dimitrova, Hristo Popov, Kameliya Bratoeva, Petar Ghenev.First line 5-fu-based chemotherapy with/ without bevacizumab formetastatic colorectal cancer: tissue biomarker candidates.J of IMAB. 2016,22;(1):1038-1044. ISSN: 1312-773X
  14. M. Radanova, K. Bratoeva, N. Nazifova-Tasinova, M. Todorova, V. Vasilev, D. Ivanova "The GG rs292001 genotype prevails in seronegative for ANA and anti-dsDNA antibodies patients with lupus nephritis." Scripta Scientifica Medica, 48(3), 34-38, 2016.
  15. Mariya Kosturkova, Galya Mihaylova, Bogdan Rousev, Desislava Ivanova, Iliyan Kolev, Kameliya Bratoeva, Ivan Shterev, Мaria Radanova. Risk of development of solid tumors in patients with systemic lupus erythematosus. Варненски медицински форум; 2018; 7(2) 7-17. ISSN 2367-5519
  16. Bratoeva K, Dimitrova E, Conev N, Kashlov J, Panajotova E, Stoyanov G, Radanova M, Donev I. Expression of hepatic HMGB1 levels in fructose- induced fatty liver. Варненски медицински форум, 2018; 7(2): 151-157. ISSN 2367-5519
  17. M. Radanova, K. Bratoeva, V. Vasilev, B. Deliyska, V. Ikonomov, T. Argirova "Association between anti-C1q and anti-dsDNA antibodies in patients with Lupus nephritis" Science & Technologies, 10 (1), 55-60, 2015.



Член на

​Dr. Kameliya Bratoeva is a member of the European Federation of Physiological Sciences and the Bulgarian Physiological Society.