Education:
Acquired specialty in Biochemistry, Medical University "Prof. Dr. Paraskev Stoyanov" Varna – 2018
Master's degree in Biology, Sofia University "St. Kliment Ohridski" – 1994
Academic Degrees and Positions:
Chief Assistant Professor, Department of Biochemistry, Molecular Medicine and Nutrigenomics, Medical University "Prof. Dr. Paraskev Stoyanov" – Varna – since 2016
PhD in Biochemistry, awarded on 26 October 2015, Medical University "Prof. Dr. Paraskev Stoyanov" – Varna
Assistant Professor, Department of Biochemistry, Molecular Medicine and Nutrigenomics, Medical University "Prof. Dr. Paraskev Stoyanov" – Varna; from 2011 to 2016
Areas of professional interest:
Biochemistry; Molecular biology; Molecular mechanisms of oxidative stress and inflammation; Screening of medicinal plants for various biological activities; Investigation of antioxidant, anti-inflammatory, immunomodulation, antidiabetic effects of plant extracts by in vitro and in vivo methods.
Research Activities:
Investigation of the biological activity of a 40% aqueous-ethanol extract of black mulberry (Morus nigra) wood in a cell culture model by: determining the total polyphenol content and antioxidant activity of the extract; determining the effect on the viability of 3T3-L1 preadipocytes and J744A.1 macrophages.
Investigation of the antioxidant and anti-inflammatory effects of the aqueous-ethanol extract by monitoring its influence on the transcription levels of genes related to oxidative status, pro-inflammatory cytokines and enzymes under conditions of t-BotOOH-induced oxidative stress and LPS-induced inflammation.
Investigation of the antiobesity potential of an aqueous-ethanol wood extract of M. nigra by determining the expression levels of genes related to lipid metabolism in differentiated adipocytes.
Participation in Research Projects and Programs:
1. 2015-2016г project №14013/18.12.2014, contract №1/18.12.2015 „Exploring the therapeutic potential of black mulberry wood as a resource for the pharmaceutical industry", funded by fund “Science" of Medical University – Varna, 2014. Coordinator prof. Dsc Diana Ivanova.
2. 2017-2019 project № Н01/42/03.09.2016. “ Study of the molecular mechanisms of action of sulfur containing mineral waters from the Varna basin on the human metabolism with a view to their use as a therapeutic-drinking water", funded by National Science Fund of the Ministry of Education and Science, competition for funding of fundamental research – 2016. Coordinator Prof. Dsc Diana Ivanova.
3. 2017-2023 project №Н13/41 contract ДН13/9/15.12.2017. „Cyanocarcinomas – a new potential risk factor for malignancies in Bulgaria?“, funded by National Science Fund of the Ministry of Education and Science – 2017. Coordinator prof. Dsc Maya Stoyneva-Gertner.
4. 2018-2020 "VITAMIN K-DEPENDENT GLA-PROTEINS – NEW BIOMARKERS FOR CARDIOVASCULAR CALCIFICATION", funded by the "Science" Fund at the Medical University of Varna, Project leader Prof. Bistra Tsaneva Galunska-Kaltcheva, PhD.
5. 2018-2020 project №17020, contract № ФМН-41/18.12.2017. „Preparation of an anthocyanin extract of Sambucus ebulus and characterization of its biological activity in relation to the establishment of an adaptogenic potential with a view to its use as a raw material in the production of food and curative substances“, funded by fund “Science" of Medical University – Varna, 2017. Coordinator assoc. prof. Yoana Kiselova-Kaneva, PhD.
6. 2018-2023 project contract № КП-06-ОПР03/18. „Algal toxins – a new risk factor for the quality of life and human health in Bulgaria“, funded by National Science Fund of the Ministry of Education and Science – 2018. Coordinator prof. dr. Hristo Gagov, PhD Sofia University “St. Kliment Ohridski".
7№ 19009, 2020 - "New molecular biomarkers for bone disease assessment in multiple myeloma", Project leader - Prof. Bistra Tsaneva Galunska, PhD.
8. Project No. 24006: Investigation of the psychopharmacological effects of Kochia scoparia seed extract in experimental models of dementia and anxiety-depressive disorder in laboratory animals. Funded by the Science Fund, Medical University – Varna. Extraordinary grant session 2024. Duration: 2024–2027. Principal Investigator: Assoc. Prof. Dr. Silvia Gancheva Marinova.
9.Project 22025, MU-Varna Science Fund: "Molecular biomarkers in children with generalized developmental disorders", Project coordinator: Prof. Dr. R. Pancheva, Department of Hygiene and Epidemiology, MU-Varna
10. Project 3.4.3 (27.03.2024 – 27.09.2025): Development of combined products of natural origin with immunomodulatory, antioxidant, and vasoprotective activity. Funded under the project Medical University – Varna: Enhancing Translational Achievements in Medicine (MUVE-TEAM), BG-RRP-2.004-0009-C02. Principal Investigator: Assoc. Prof. Oskan Tasinov.
European Nutrigenomics Association – NuGO
Union of Scientists in Bulgaria section Biochemistry, Biophysics and Molecular Biology
Union of Scientists – Varna Branch
Association of Biochemical Departments in Bulgaria
