Education:
Higher education: Paisiy Hilendarski University, biology with specialization in genetics and cell biology, 1999
Acquired scientific degrees and academic positions held:
MU-Varna - Educational and scientific degree "Doctor" - 2011
Academic title "Associate Professor" - 2013
JSC "Professor" - 2023
Areas of professional interest:
Nutrigenomics and personalized nutrition, molecular markers, functional foods
Specializations and work abroad:
Training "Navigate Your Path to a Resilient Future: Policy Workshop to Establish Robust Security Cultures and Empower Women Leaders in Tech", December 4-5, 2024, Krakov, Poland
Training "Technology Transfer Ecosystem", November 1, 2024, Faculty of Pharmacy, MU-Varna, within the framework of the Second Annual Conference and Meeting of the Steering Committee with the Advisory Board of the MUVE-TEAM project.
Training for innovation and technology transfer "Supersonic THE&KNOWLEDGE TRANSFER", November 12, 2024, SofiaTechPark, Sofia.
Course "Joint SFRR-Europe/IUBMB/FEBS Advanced Lecture Course 2024 “Redox biochemistry: Cellular Responses and Disease Relevance", 30 September – 06 October, 2024, Spetses, Greece
Training "Digital Skills (Intensive Training)" under project №BG05M2OP001-2.016-0025 "Creating a multidisciplinary educational environment for the development of personnel with integral competencies in the field of biomedicine and healthcare", training period 11-13.03.2022
Training "Gene expression regulation: a computational point of view" Scientific Research Institute of Medical Universities - Varna, training period 18-19.11.2021
Course "Fundamentals of stem cell transplantation", 10.10.2016-04.11.2016, Medical University - Varna
Specialization within the COST Action BM0602 "Adipose Tissue: A Key Target for Prevention of the Metabolic Syndrome", May 11-22, 2009, University of Liverpool, School of Clinical Sciences, Obesity Biology Research Unit, Liverpool, UK
Advanced FEBS course "Mechanisms, consequences and detection of free radical-mediated oxidative protein modifications", April 15-20, 2009, Antalya, Turkey
Summer school "Identification of Proteins and post-translational modifications by mass spectrometry", August 24–29, 2008, Brussels, Belgium, in the frame of COST Action BM0602: Adipose Tissue: A Key Target for Prevention of the Metabolic Syndrome
Short specialization in Faculty of Pharmacy, "Ovidius" University, 20.11–1.12. 2006 Constanta, Romania
Summer FEBS school "Free radicals and diseases: gene expression, cellular metabolism and pathophysiology", 20.09–1.10, 2004, Spetses, Greece
Participation in contracts, projects, programs
With international funding
1. 27.03.2024 – 27.09.2025 Project 3.4.2 “Panel genetic biomarkers in colorectal carcinoma", funded under the project “Medical University - Varna: Enhancing translational achievements in medicine (MUVE-TEAM)" BG-RRP-2.004-0009-C02. Scientific supervisor: Prof. Yoana Kiselova-Kaneva, PhD,
2. 27.03.2024 – 27.09.2025 Project 3.4.3 “Development of combined products of natural origin with immunomodulatory, antioxidant and vascular protective effects", funded under the project “Medical University - Varna: Enhancing translational achievements in medicine (MUVE-TEAM)" BG-RRP-2.004-0009-C02. Scientific advisor: Assoc. Prof. Oskan Tasinov,
3. 2022-2026 “Medical University - Varna: Enhancing translational achievements in medicine (MUVE-TEAM). Budget 28 million BGN European Union, National Recovery and Resilience Plan of Bulgaria under the procedure for “Establishing a network of research universities in Bulgaria".
4. Application of new technologies and methods in nutrition research – the example of phenotypic flexibility – NutriTech; 2012 – 2016; Project leader from the Bulgarian side – Prof. Diana Ivanova, PhD
5. AdiposeTissue: A Key Target for Prevention of the Metabolic Syndrome, 2007 -2011); Co-financing of a project under the 7th FP of the EC for research, technological development and demonstration activities and the COST Programme for European Cooperation in the field of science and technology "Adipose tissue – a key target for metabolic syndrome" – financed by the Scientific Research Fund at the Ministry of Education and Science (2010-2011); Project leader from the Bulgarian side – Prof. Diana Ivanova, PhD
Financed by the Scientific Research Fund, Ministry of Education and Science
1. Cyanoprokaryotes – a new potential risk factor for malignant diseases in Bulgaria?; 2017 -2019; Basic organization SU-Sofia
2. Study of the molecular mechanisms of action of sulfur-containing mineral waters from the Varna basin on human metabolism with a view to their use as a medicinal and drinking agent; 2016 - 2018
3. Preparation of an anthocyanin-rich extract of elderberry fruits (Sambucus ebulus) and characterization of its biological activity in connection with the establishment of adaptogenic potential with a view to its use as a raw material in the production of food and medicinal products; 2018 -2020
Science Fund at MU - Varna
6. Tissue and serum expression of Nrf2, NF-KB, HO-1, 4-HNE and their potential as biomarkers of endothelial dysfunction in an experimental model of metabolic syndrome; 2018-2020
7. Determination of biological activity and antioxidant properties of newly synthesized bexarotene analogues; 2018 -2020
8. Preparation of an anthocyanin-rich extract from elderberry (Sambucus ebulus) fruits and characterization of its biological activity in connection with the establishment of adaptogenic potential with a view to its use as a raw material in the production of foods and medicinal products; 2017 -2019 Project leader - Assoc. Prof. Yoana Kiselova-Kaneva, PhD
9. “Study of single nucleotide polymorphisms in non-coding RNAs in patients with colorectal carcinoma with the aim of identifying new diagnostic, prognostic and predictive biomarkers for the Bulgarian population", (2017-2019)
10. Vitamin K Dependent Gla-proteins – new biomarkers for cardiovascular calcification; 2018 -2020
11. Study of the gene expression of some poorly studied proteins and microRNAs with a view to their application as molecular markers in patients with colorectal carcinoma; 2016 -2018
12. "Study of the relationship between the presence of some polymorphisms in the FTO, ADIPO Q and ADIPO R2 genes and the risk of high-grade obesity and metabolic syndrome in a representative sample of the Bulgarian population (2009-2010)
13. "Study on an experimental model of metabolic syndrome: the protective effect and evaluation of the anti-inflammatory, antioxidant and anti-hyperlipemic effects of plant extracts with a high content of polyphenols as a potential resource for nutraceuticals (2009-2010)
14. Improving the infrastructure of the center for translational medicine and cell therapy and creating the first corneal tissue and sclera bank outside Sofia - city; 2019 -2021
15. "Study of plasma levels and expression of leptin and adiponectin to assess their applicability as molecular biomarkers in colorectal carcinoma", funded by Science Fund of MU-Varna (2019-2021)
16. Identification of biomarkers in saliva for assessing the risk profile of gingival health in childhood", funded by the Science Fund of MU-Varna (2019-2021)
17. Algotoxins - a new risk factor for the quality of life and health of people in Bulgaria", in partnership with Sofia University "St. Kliment Ohridski", funded by the Scientific Research Fund (2018-2021)
18. Lipid nanoparticles - a modern technological approach for incorporating hyperforin with improved chemical stability into le
Scientific publications
Open Access
Research activities
The effect of some natural products, diets and nutritional habits on selected biochemical and molecular markers is investigated by applying different model systems. The research activity includes the application of in vitro and in vivo analysis methods for the purpose of selection and screening of natural products for the presence of specific biological activity - antioxidant, anti-inflammatory, immunomodulatory, antidiabetic, etc. The obtained results are relevant for the application of the studied products as means for the prevention and treatment of diseases and as raw materials for the production of food and medicinal products. Qualitative and quantitative analyzes of biologically active substances, cytotoxicity analyses, study of molecular mechanisms of biological activity in in vitro experiments, including on cell cultures and in vivo on experimental animals, are carried out. Interventional studies involving healthy volunteers and those with compromised health status are being conducted,
Assoc. Prof. Yoana Kiselova-Kaneva has more than 65 publications and more than 60 participations in Bulgarian and international scientific congresses.
Scientific interests: oxidative stress and related diseases, antioxidants, biological activity of medicinal plants
Selected Publications:
1. Hristova M, Tasinov O., Tzaneva M., Chivchibashi D., Kiselova-Kaneva Y., Bekyarova G., 2022. Effect of melatonin on gastric antioxidant defense in experimental burn trauma. Veterinarni Medicina 67(7), 379-396. (IF: 0.565, Q3)
2. Tasinov O., Dincheva I., Badjakov I., Kiselova-Kaneva Y., Galunska B., Nogueiras R. and Ivanova D., 2021. Phytochemical composition, anti-Inflammatory and ER stress-reducing potential of Sambucus ebulus L. fruit extract. Plants, 10 (11):2446. https://doi.org/10.3390/plants10112446 (IF: 3.935, Q1)
- Tasinov O., Kiselova-Kaneva Y., Ivanova D., Pasheva M., Vankova D. and Ivanova D., 2021. Ferrum phosphoricum D12 Treatment Affects J774A.1 Cell Proliferation, Transcription Levels of Iron Metabolism, Antioxidant Defense, and Inflammation-related Genes. Homeopathy, online. https://doi.org/10.1055/s-0041-1731312 (IF:1.444, Q2)
4. Sokrateva T., Roussev B., Nashar M., Kiselova-Kaneva Y., Mihaylova G., Todorova M., Pasheva M., Tasinov O., Nazifova-Tasinova N., Vankova D., Ivanova D.P., Radanova M., Galunska B., Vlaykova T., Ivanova D.G. 2019. Effects of sulphur-containing mineral water intake on oxidative status and markers for inflammation in healthy subjects. Archives of Physiology and Biochemistry, (IF:2.11 (2018), Q2) DOI: 10.1080/13813455.2019.1638416.
5. Hristova M, Tzaneva M, Bekyarova G, Chivchibashi D, Stefanova N, Kiselova-Kaneva Y. 2018. Molecular Mechanisms of Melatonin Protection from Gastric Mucosal Apoptotic Injury in Experimental Burns. Molecules, 23, 4, 749 (IF: 2.861)
6. Fiamoncini J, Rundle M, Gibbons H, Thomas E.L, Geillinger-Kästle K, Bunzel D, Trezzi J, Kiselova-Kaneva Y et al. 2018. Plasma metabolome analysis identifies distinct human metabotypes in the postprandial state with different susceptibility to weight loss–mediated metabolic improvements. The FASEB Journal, in press. (IF: 5.498)
7. M.N. Todorova, M. G. Pasheva, Y. D. Kiselova-Kaneva, D. G. Ivanova, B. Tz. Galunska. Phenolics content and antioxidant activity of beverages on the Bulgarian market – wines, juices and compotes. Bulgarian Chemical Communications, 2018;50:164 – 168, Special Issue C (IF 0.349).
8. Ivanova D, Tasinov O, Kiselova-Kaneva Y. 2014. Improved lipid profile and increased serum antioxidant capacity in healthy volunteers after Sambucus ebulus L. fruit infusion consumption. International Journal of Food Sciences and Nutrition, V 65(6): 740-744. (IF: 1.206)
9. Ivanova D., Tasinov O., Kiselova-Kaneva Y. 2014. Improved lipid profile and increased serum antioxidant capacity in healthy volunteers after Sambucus ebulus L. fruit infusion consumption. International Journal of Food Sciences and Nutrition, V 65(6), 740-744. (IF:1,26).
10. Kiselova Y., Ivanova D., Chervenkov T., Gerova D., Galunska B., Yankova T. (2006). Correlation between the in vitro antioxidant activity and polyphenol content of aqueous extracts from Bulgarian herbs. Phytother Res, 20, 11, 961-965.
Monographs
Kiselova-Kaneva, Y. (2013). Biological effects of oxidative stress and herbs as countermeasures. Antida, 2013, ISBN 978-619-90019-3-6. (in Bulgarian)
