Education:
2011- Master's degree in "Analysis and control of food and water", University "Professor Dr. Asen Zlatarov" - Burgas
2010 - Master's degree in Industrial Biotechnologies, University "Professor Dr. Asen Zlatarov" - Burgas
2002-Master's degree in Biology and Chemistry, „Konstantin Preslavsky" University of Shumen
Scientific degrees obtained and academic positions held:
2019-Educational and Scientific Degree "Doctor" in Biochemistry, Medical University "Prof. Dr. Paraskev Stoyanov" Varna
Specializations:
2021-Specialization in Biochemistry, Medical University "Prof. Dr. Paraskev Stoyanov" Varna
Areas of professional interest:
Clinical Biochemistry, Biochemistry of Nutrients, Biochromatography, Biotechnology, Phytochemistry of Medicinal Plants, Nutrition, Food and Quality of Life, Oxidative Stress, Antioxidants, Molecular Biology
Membership in scientific organizations:
Union of Scientists in Bulgaria - Section of Molecular Biology, Biochemistry and Biophysics (member of FEBS)
European Nutrigenomics Association – NuGO
Association of Biochemical Departments in Bulgaria
Scientific and research activities:
Fractionation, purification and determination of phytochemical composition and antioxidant activity of extracts from fruits of Sambucus ebulus and other medicinal plants in order to study their anti-inflammatory and antioxidant effects in experimental models of lipopolysaccharide-stimulated inflammatory response in macrophage cell cultures. Analyzing the molecular mechanisms of the cytoprotective, immunostimulating, anti-inflammatory, antioxidant action of acetone extracts of Sambucus ebulus. Analyzing and evaluating the biochemical changes and the changes in the transcriptional levels of selected molecules, by applying modern molecular biological methods.
Development and validation of chromatographic methods for determining serum levels of the circulating form of vitamin D – 25-hydroxy vitamin D. Study of vitamin D status in patients with cardiac diseases.
Study of the effect of some cyanotoxins released during the bloom of cyanoprokaryotes on the incidence of cancer in the Bulgarian population. Cytotoxicity assessment of cyanotoxins in cultured human epidermal cell lines.
Biotransformation of pharmaceuticals with estrogenic activity from wastewater and soil using immobilized enzymes from Trametes versicolor.
Participation in contracts, projects, programs
"MOLECULAR MECHANISMS OF ACTION OF CYTODEОX: NEW DATA IN SUPPORT OF NEUROPROTECTIVE AND ANTIOXIDANT EFFECTS", funded by the "Science" Fund at the Medical University of Varna, Project leader Assoc. Prof. Milka Nashar, PhD, implementation period 2022-2025
"STUDY OF ADAPTOGENIC POTENTIAL OF SAMBUCUS EBULUS FRUITS IN RESPECT OF THEIR USE AS A FUNCTIONAL FOOD", funded by the Scientific Research Fund, Project Leader Assoc. Prof. Yoana Kiselova-Kaneva, PhD, implementation period 2019 – 2021
„ALGOTOXINS - A NEW RISK FACTOR FOR THE QUALITY OF LIFE AND HEALTH OF PEOPLE IN BULGARIA", funded by the "Scientific Research" Fund, Project Leader Prof. Hristo Gagov, implementation period 2018-2020
„OBTAINING OF RICH IN ANTHOCYANINS EXTRACT FROM ELDERBERRIES (Sambucus ebulus) AND CHARACTERIZING ITS BIOLOGICAL ACTIVITY IN CONNECTION WITH ESTABLISHING ADAPTOGENIC POTENTIAL IN REGARDS OF ITS USE AS A RAW MATERIAL FOR FOODS AND MEDICINAL PRODUCTS" funded by the "Science" Fund at the Medical University of Varna, Project leader Assoc. Prof. Yoana Kiselova-Kaneva, PhD, implementation period 2018-2020
"EXPRESSION PROFILING OF NON-CODING RNAS IN COLORECTAL CARCINOMA." Scientific Research Fund at the Ministry of Education and Science. Project Leader Assoc. Prof. Maria Atanasova Radanova, PhD, implementation period 2018-2020
"IDENTIFICATION OF BIOMARKERS IN SALIVA TO ASSESS THE RISK PROFILE OF GINGIVAL HEALTH IN CHILDHOOD." Science Fund at the MU - Varna. Project Leader Prof. Diana Ivanova, DSc implementation period 2018-2020
"MOLECULAR MECHANISMS OF ACTION OF SULFUR-CONTAINING MINERAL WATERS FROM VARNA BASIN ON HUMAN METABOLISM WITH REGARD TO THEIR USE AS DRINKING REMEDIES", funded by the "Scientific Research" Fund, Project Leader Prof. Diana Ivanova, implementation period 2017-2018
„STUDY OF THE EFFECTS OF SULFUR-CONTAINING MINERAL WATERS ON THE HUMAN METABOLISM OF SULFUR", funded by the "Science" Fund at the Medical University of Varna, Project Leader Assoc. Prof. Milka Nashar, implementation period 2018
Scientific Publications
Todorova M., Pasheva M., Tasinov O., Kiselova-Kaneva Y. 2020. LPS-induced response in J774A.1 macrophage cell culture – indicative markers for stimulated antioxidant defense, inflammation and phagocytosis. Scripta Scientifica Pharmaceutica, 7, 2. doi:http://dx.doi.org/10.14748/ssp.v7i2.6678
Tasinov O. B., Kiselova-Kaneva Y. D., Nazifova-Tasinova N. F., Todorova M. N., Trendafilova A. B., Ivanova D. G. 2020. Chemical composition and cytoprotective and anti-inflammatory potential of Sambucus ebulus fruit ethyl acetate fraction. Bulgarian Chemical Communications, D, 52, 100-106. (Q4).
Todorova M., Tasinov O., Pasheva M., Kiselova-Kaneva Y., Galunska B. 2020. Sambucus ebulus extracts exibit modulatory activity on inflammation and phagocytosis as revealed by changed gene expression in a model of LPS treated J774A.1 macrophages. Bulgarian Chemical Communications, D, 52, 142-148. (Q4).
Todorova M. N., Y. D. Kiselova-Kaneva, I. Y. Potoroko, I. V. Kalinina, D. G. Ivanova, B. T. Galunska (2019): Antioxidant activity of taxifolin derived from larch: synergistic studies. .Bulgarian Chemical Communications, BCC-51-A9 (pp. 172-176) (IF: 0.318)
Sokrateva T, Roussev B, Nashar M, Kiselova-Kaneva Y, Mihaylova G, Todorova M, Pasheva M, Tasinov O, Nazifova-Tasinova N, Vankova D, Ivanova DP, Radanova M, Galunska B, Vlaykova T and Ivanova DG. Effects of sulfur-containing mineral water intake on oxidative status and markers for inflammation in healthy subjects. Archives of Physiology and Biochemistry (IARP), 2019 [E-pub] (https://doi.org/10.1080/13813455.2019.1638416)
Daniela V. Vankova, Miglena N. Todorova, Yoana D. Kisselova-Kaneva & Bistra Ts. Galunska (2019): Development of new and robust LC-MS method for simultaneous quantification of polyphenols from Sambucus ebulus fruits, Journal of Liquid Chromatography & Related Technologies, DOI: 10.1080/10826076.2019.1614053.
Miglena TODOROVA, Oskan TASINOV, Milena PASHEVA, Diana IVANOVA, Bistra GALUNSKA, Yoana KISELOVA-KANEVA. 2019. Cytoprotective activity of Sambucus ebulus fruit extracts in conditions of tert-Buthylhydroperoxyde induced cell toxicity, Bulgarian Chemical Communications, BCC-51-A9 (pp. 125 - 130) (IF: 0.318)
Sokrateva T, Ivanova D, Galunska B, Todorova M, Ivanov D. 2018. Physicochemical analysis of Varna basin mineral water. 18 International Multidisciplinary Scientific GeoConference SGEM 2018, Conference proceedings Vol. 18, Book number 3.1. Water resources. Forest, marine and ocean ecosystems., page 555-564. 10.5593/sgem2018/3.1/S12.072.
Todorova M.N., M. G. Pasheva, Y. D. Kiselova-Kaneva, D. G. Ivanova, B. Tz. Galunska. Phenolics content and antioxidant activity of beverages on the Bulgarian market – wines, juices and compotes. Bulgarian Chemical Communications, 2018;50:164 – 168, Special Issue C (IF 0.349).
