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Medical University - Varna
Prof. Dr. Paraskev Stoyanov

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Ch. Assist. Prof. Stanila Seryozheva Stoeva-Grigorova MscPharm, PhD


Катедра: Pharmacology, toxicology and pharmacotherapy
 УС:
 Е-поща: Stoeva.ST@mu-varna.bg
Телефон: 052 677 050/ вътр. 2944

 

Биография

Stanila Stoeva-Grigorova was born in 1992 in Silistra, Bulgaria, where she graduated with distinction from the Secondary School of Mathematics and Natural Sciences “St. Kliment Ohridski" (with intensive study of Biology and Chemistry).

In 2017, she completed her Master's degree in Pharmacy with distinction at the Faculty of Pharmacy, Medical University 'Prof. Dr. Paraskev Stoyanov' in Varna. During her studies, she served as head of the Committee for Public Activities and Campaigns at the Association of Pharmacy Students – Varna (AFSV). In 2015, she was awarded the annual scholarship of the Bulgarian Pharmaceutical Union for pharmacy students.

In 2016, she participated in a summer internship program in pharmaceutical practice at the First Moscow State Medical University “I.M. Sechenov," Russia. In 2017, she underwent training in the use of a modular high-performance liquid chromatography system (Thermo Scientific UltiMate 3000 HPLC), configured with quaternary pump, UV-VIS, DAD, and fluorescence detectors.

Since 2018, she has held the position of pharmacist specializing in drug product analysis at the Department of Pharmacology, Toxicology, and Pharmacotherapy, Medical University – Varna. She currently leads the department's chromatographic analysis laboratory.

In 2019, she completed a certified course on “Protection and Humane Treatment of Laboratory Animals Used for Scientific or Educational Purposes." In 2021, she successfully defended her PhD dissertation titled: “New Aspects in the Liquid Chromatographic Analysis of Capecitabine in Biological and Non-Biological Samples," earning a PhD degree.

In the same year, she was appointed Chief Assistant Professor in the Department of Pharmacology, Toxicology, and Pharmacotherapy. In 2024, she obtained a specialization in Pharmacology and Pharmacotherapy at the Medical University – Varna.


Публикации

Textbooks and Educational Materials

  1. Textbook of Toxicology for Pharmacy Students. Authors: Marieta Petrova Georgieva, Kaloyan Dobrinov Georgiev, Petko Penkov Marinov, Nadezhda Rumenova Hvarchanova, Stanila Seryozheva Stoeva. Edited by Prof. Dr. Marieta Georgieva, MD, 2020, Medical University – Varna Publishing House. ISBN: 978-619-221-292-6, 76 pages. [Language: Bulgarian]
  2. Theses in Toxicology for Pharmacy Students. Authors: Marieta P. Georgieva, Kaloyan D. Georgiev, Nadezhda R. Hvarchanova, Stanila S. Stoeva, Maya P. Radeva-Ilieva. Edited by Prof. Dr. Marieta Georgieva, MD, 2022, Steno Publishing. ISBN: 978-619-241-224-1, 64 pages.
  3. Test Questions in Toxicology for Master-Pharmacists. Authors: M.P. Georgieva, K.D. Georgiev, N.R. Hvarchanova, S.S. Stoeva, M.P. Radeva-Ilieva. Edited by Prof. Dr. Marieta Georgieva, MD, 2022, Steno Publishing. ISBN: 978-619-241-247-0, 64 pages.
  4. Test Questions in Pharmacology and Toxicology for Pharmacists. Authors: Prof. Dr. Marieta Georgieva, Prof. Kaloyan Georgiev, PhD, Assoc. Prof. Nadezhda Hvarchanova, PhD, Assoc. Prof. Stanila Stoeva, PhD. Edited by Prof. Dr. M. Georgieva and Prof. K. Georgiev, 2022, Steno Publishing. ISBN: 978-619-241-251-7, 143 pages.
  5. Monograph – Toxicochemical Screening of Drug Abuse – Possibilities and Limitations. Steno Publishing, Varna, 2023, 136 pages. ISBN: 978-619-241-291-3
  6. Stanila Stoeva*, Marieta Georgieva. Chapter 23. Aflatoxigenic fungi: A potential human carcinogen. In:  Aflatoxigenic Fungi: Consequences on Living Systems, CRC Press, Taylor and Francis Publications, in press.
  7. Stanila Stoeva*, Maria Petrova, Marieta Georgieva. In vivo determination of acute and chronic toxicity. In: Biosafety Assessment of Probiotic Potential (2nd Ed.), Springer Nature publications, in press.

Publications:

  1. Stoeva, S.*, Kolev, I., Sabeva, Y. (2018). Development and validation of a new rapid and simple HPLC-UV method for the assay of Capecitabine in pharmaceutical preparations. Proceedings of the National Scientific Conference “15 Years of Pharmacy at Medical University – Plovdiv, ISBN 978-619-237-013-8 (CD), ISBN 978-619-237-014-5 (online).
  1. Petko Marinov, Dobri Ivanov, Snezha Zlateva, Simeonka Dimitrova, Gabriela Kehayova, Maya Radeva, Stanila Stoeva. Intravenous lipid emulsion infusion in acute intoxication with fenitrothion. Scripta Scientifica Pharmaceutica, 2018;5(1):47-50.
  2. Georgiev, K.D., Radeva-Ilieva, M., Stoeva, S., Zhelev, I. Isolation, analysis and in vitro assessment of CYP3A4 inhibition by methylxanthines extracted from Pu-erh and Bancha tea leaves. Scientific Reports 9, 13941 (2019) doi:10.1038/s41598-019-50468-7, IF 4.1.
  3. Ivanova, N., Stoeva, S., Kolev, Il., Hydrolytic stability of diltiazem in the presence of chosen polymers-Poloxamer 407 and Ammonio Metacrylate Copolymer Type B (Eudragit RS): а preliminary study. Scripta Scientifica Pharmaceutica, 2019;6(1):17-21.
  4. N. Agova, S. Georgieva, St. Stoeva, S. Stamova, J. Mitkov. HPLC method for analyzing new compounds – analogs of an antineoplastic drug. Bulgarian Chemical Communications, 2020; 52(A):9-16.  doi: 10.34049/bcc.52.A.271, IF 0.349.
  5. Maya P. Radeva-Ilieva, Kaloyan D. Georgiev, Nadezhda R. Hvarchanova, Stanila S. Stoeva, Iliya J. Slavov, Deyan L. Dzhenkov, Marieta P. Georgieva. Protective Effect of Methylxanthine Fractions Isolated from Bancha Tea Leaves against Doxorubicin-Induced Cardio- and Nephrotoxicities in Rats. BioMed Research International, vol. 2020, Article ID 4018412, 9 pages, 2020. https://doi.org/10.1155/2020/4018412, IF 2.276
  6. Stanila Stoeva*, Nikolay Conev, Petko Marinov. The role of carboxylesterase enzymes in capecitabine therapy. Scripta Scientifica Pharmaceutica, 2020; 7(1):7-17.
  7. Hvarchanova, N., Georgieva, M., Radeva-Ilieva, M., Stoeva, S., Georgiev, K. (2020). The sea as a source of bioactive compounds. Varna Medical Forum, 9(Suppl. 1).
  8. Stanila Stoeva*, Petko Marinov. Analytical protocol for monitoring of workplace surface contamination with Capecitabine. Current Pharmaceutical Analysis, 2021; 17: 1. https://doi.org/10.2174/1573412917666201217164305, IF 0.923.
  9. Hvarchanova N, Stoeva S, Radeva-Ilieva M, Georgieva М. New pharmacotherapeutic options for the treatment of heart failure with reduced ejection fraction. Cardiovascular diseases, 2021, 52, № 2, 9-17.
  10. Maya Radeva-llieva, Stanila Stoeva, Nadezhda Hvarchanova, Iliya Zhelev, Kaloyan D. Georgiev. Influence of methylxanthines isolated from Bancha green tea on the pharmacokinetics of sildenafil in rats. DARU Journal of Pharmaceutical Sciences, 2022; https://doi.org/10.1007/s40199-022-00433-z , IF 2.69.
  11. Stoeva Stanila*, Radeva–Ilieva Maya, Zhelev Iliya and Georgiev Kaloyan. A HPLC-UV Method for Analysis of Total Plant Extract and Catechin Fraction of Bancha Green Tea, The Natural Products Journal. 2023; 13(2): e120522204703. https://dx.doi.org/10.2174/2210315512666220512212448 , IF 1.015.
  12. Maria Petrova, Stanila Stoeva, Nadezhda Hvarchanova, Marieta Georgieva. Sea climate therapy—a current overview and possibilities for application in Bulgaria. Varna Medical Forum. 2022;11(2): 203-207. http://dx.doi.org/10.14748/vmf.v11i2.8590
  13. Maria Petrova, Stanila Stoeva, Nadezhda Hvarchanova, Marieta Georgieva. Medical supplies on ships. Varna Medical Forum. 2022; 11(2): 208-212. http://dx.doi.org/10.14748/vmf.v11i2.8591
  14. Nihal Kyazim, Stanila Stoeva*, Marieta Georgieva. Louis Pasteur: 200 years since the birth of the father of microbiology (1822–1895). Varna Medical Forum. 2022; 11(2): 218-221. http://dx.doi.org/10.14748/vmf.v11i2.8719
  15. Ivaylo Pehlivanov, Stanila Stoeva, Apostol Simitchiev, Stanislav Stefanov, Velichka Andonova. Stability study of extemporaneously compounded nitrofurantoin oral suspensions for pediatric patients. Folia Medica (Plovdiv). 2022; 64(5): 807-816. doi: 10.3897/folmed.64.e72334, IF 0.54.
  16. Iliyan Nikolov Kolev, Stanila Seryozheva Stoeva, Ivan Angelov Iliev, Petko Penkov Marinov. A small-scale method of sample preparation suitable for simultaneous HPLC-UV assay of capecitabine and its 5'-DFCR metabolite in mouse blood plasma. Braz. J. Pharm. Sci. 2022; 58: e201043. https://doi.org/10.1590/s2175-97902022e201043 IF 1.321
  17. Stefanov S, Stoeva S, Georgieva S, Hristova M, Nikolova K, Dobreva M, Andonova V. In vivo comparative assessment of incised wound healing in rats after application of hydrogel/organogel formulation containing St. John's wort methanol extract. Bulgarian Chemical Communications, 2022; 54:(Special Issue B2): 46-51. DOI: 10.34049/bcc.54.B2.0467, IF 0.14
  18. Nadezhda Hvarchanova, Stanila Stoeva*, Maya Radeva-Ilieva, Iliya Zhelev, Marieta Georgieva, Deyan Dzhenkov, Kaloyan D. Georgiev. Cardio- and nephroprotective effects of fractions isolated from Lycium barbarum (goji berry) in models of cardio- and nephrotoxicity in rats, Biotechnology & Biotechnological Equipment, 2023; 37:1, 64-73, https://doi.org/10.1080/13102818.2022.2155571 . IF 1.632
  19. Yoana Sotirova, Viliana Gugleva, Stanila Stoeva, Iliyan Kolev, Rositsa Nikolova, Maria Marudova, Krastena Nikolova, Yoana Kiselova-Kaneva, Minka Hristova, Velichka Andonova. Bigel Formulations of Nanoencapsulated St. John'sWort Extract—An Approach for Enhanced Wound Healing. Gels, 2023, 9(5), 360.  https://doi.org/10.3390/gels9050360 , IF 4.432
  20. Sotirova Y, Stoeva S, Nikolova R, Andonova V. Nanostructured Lipid Carriers as a Promising Dermal Delivery Platform for St. John's Wort Extract: Preliminary Studies. J of IMAB. 2023, 29(2): 4911-4919. https://doi.org/10.5272/jimab.2023292.4911
  21. Stoeva, S.*, Georgieva, M., Georgiev, K., Khvurchanova, N., Radeva-Ilieva, M., Tsankova, V., Kondeva-Burdina, M., Aluani, D., Tsaneva, M. (2025). Assessment of antioxidant and hepatoprotective activity of probiotic food LDB-ST against paracetamol-induced liver damage in rats. Comptes rendus de l'Académie bulgare des Sciences, 78(2): 261–268. https://doi.org/10.7546/CRABS.2025.02.12
  22. Stanila Stoeva*. DOES MODERN CHEMICAL ANALYSIS ALLOW THE IDENTIFICATION OF PASSIVE CANNABIS SMOKERS? Varna Medical Forum. 2023;12:(Online First https://journals.mu-varna.bg/index.php/vmf/article/view/9192)
  23. Stoeva Stanila*, Common Causes of False Positive and False Negative Results in Amphetamine Screening Tests. Current Analytical Chemistry. 2023; 19(8):571-576. (Online first www.eurekaselect.com/article/135552) https://dx.doi.org/10.2174/0115734110275100231020111633) IF 1.8
  24. Stoeva Stanila. POSSIBLE REASONS FOR THE OCCURRENCE OF FALSE- NEGATIVE RESULTS IN URINE DRUG SCREENING. Scripta Scientifica Pharmaceutica. 2023; (online first https://journals.mu-varna.bg/index.php/ssp/article/view/9227)
  25. Maria Petrova, Stanila Stoeva, Marieta Georgieva. HEALTH RISKS ARISING FROM FOLLOWING A VEGETARIAN OR VEGAN DIET. Varna Medical Forum. 2023;12:(Online First https://journals.mu-varna.bg/index.php/vmf/article/view/9304/8201)
  26. Maya   Radeva-Ilieva, Stanila   Stoeva, Nadezhda   Hvarchanova, Marieta   Georgieva, Iliya   Slavov, Kaloyan   D. Georgiev, A Study of the Effect of Bancha Green Tea Extract and Catechin Fractionon Sildenafil Pharmacokinetics in Rats. Current Traditional Medicine. 2024; 10: e310724232511. https://dx.doi.org/10.2174/0122150838305894240724112703 IF 0.6
  27. Maya Radeva-Ilieva, Stanila Stoeva, Nadezhda Hvarchanova, Kaloyan D Georgiev. Green Tea: Current Knowledge and Issues. Foods. 2025; 14(5): 745. https://doi.org/10.3390/foods14050745 IF 4.7
  28. Stoeva-Grigorova S, Radeva-Ilieva M, Dragomanova S, Kehayova G, Dimitrova S, Marinov S, Marinov P, Yovcheva M, Ivanova D, Zlateva S. A 20-Year Retrospective Analysis of Plant Poisoning Cases at the Naval Hospital, Varna, Bulgaria. Toxins. 2025; 17(4):197. https://doi.org/10.3390/toxins17040197 IF 3.9
  29. Stoeva-Grigorova S, Dragomanova S, Radeva-Ilieva M, Kehayova G, Dimitrova S, Marinov S, Marinov P, Yovcheva M, Ivanova D, Zlateva S. Poisoning from Alocasia × amazonica Roots: A Case Report. Toxins. 2025; 17(4):189. https://doi.org/10.3390/toxins17040189 IF 3.9
  30. Stanila Stoeva-Grigorova, Maya Radeva-Ilieva, Nadezhda Karkkeselyan, Stela Dragomanova, Gabriela Kehayova, Simeonka Dimitrova, Maria Petrova, Snezha Zlateva, Petko Marinov. Historical Perspectives and Emerging Trends in Fentanyl Use. Part 1: Pharmacological profile. Pharmacia. 2025; in press. IF 1.1
  31. Stanila Stoeva-Grigorova, Maya Radeva-Ilieva, Nadezhda Karkkeselyan, Stela Dragomanova, Gabriela Kehayova, Simeonka Dimitrova, Maria Petrova, Snezha Zlateva, Petko Marinov. Historical Perspectives and Emerging Trends in Fentanyl Use. Part 2: Fentanyl Overdose and Misuse. Pharmacia. 2025; in press. IF 1.1
  32. Klementina Moneva-Marinova, Silvia Gancheva, Nadezhda Hvarchanova, Marieta Georgieva, Stanila Stoeva-Grigorova, Maya Radeva-Ilieva, Kaloyan D. Georgiev. Effects of meldonium on the behavior of rats in a model of lipopolysaccharide-induced systemic inflammation. Pharmacia. 2025; Pharmacia 72: 1–7. In press IF 1.1​

Participation in Scientific Projects

  1. Participation in Project No. 14001, "Novel Polymeric Drug Delivery Forms with Potential Antitumor Activity", led by Assoc. Prof. Rumyana Cherkezova, funded by the Science Fund of the Medical University “Prof. Dr. Paraskev Stoyanov" – Varna (2015).
  2. Participation in Project No. 18027, "Lipid Nanoparticles – A Modern Technological Approach for Incorporation of Hyperforin with Enhanced Chemical Stability into Topical Dosage Forms for Accelerated Wound Healing", led by Assoc. Prof. Velichka Yordanova Andonova, PhD, funded by the Science Fund of the Medical University “Prof. Dr. Paraskev Stoyanov" – Varna (2018).
    – Administrative coordinator since June 2021.
  3. Participation in Project No. 19029, "Investigation of the Influence of Specific Carboxylesterase Inhibitors on the Efficacy of Chemotherapy with Capecitabine", led by Prof. Dr. Petko Marinov, MD, funded by the Science Fund of the Medical University “Prof. Dr. Paraskev Stoyanov" – Varna (2019).
  4. Participation in Project No. 20016, "Pharmaceutical Development and Characterization of Viscoelastic and Bioadhesive Therapeutic Systems with Silver Nanoparticles and Their Complexes for Potential Application in Oncological and Infectious Diseases of the Skin and Mucosa", led by Assoc. Prof. Velichka Yordanova Andonova, PhD, funded by the Science Fund of the Medical University “Prof. Dr. Paraskev Stoyanov" – Varna (2020).
  5. Participation in Project No. 20008, "Toxicity Evaluation of Bexarotene Hydrazones Using In Vitro and In Vivo Models", led by Assoc. Prof. Svetlana Fotkova Georgieva, PhD, funded by the Science Fund of the Medical University “Prof. Dr. Paraskev Stoyanov" – Varna (2020).
  6. Participation in Project No. 20019, "Pharmacological Study of a Methylxanthine Fraction Isolated from Green Tea", led by Assoc. Prof. Kaloyan Dobrinov Georgiev, PhD (PharmD), funded by the Science Fund of the Medical University “Prof. Dr. Paraskev Stoyanov" – Varna (2020).
  7. Participation in Project No. 21001, "Development of a Green Method for Extraction of Phycocyanin from Spirulina with Potential Applications in Pharmacy and Food Technology", led by Prof. Krastena Nikolova, PhD, funded by the Science Fund of the Medical University “Prof. Dr. Paraskev Stoyanov" – Varna (2021).
  8. Participation in the national project, "Investigation of the Immunostimulatory and Protective Effects of Probiotic Food by Monitoring Changes in Physiological, Biochemical Parameters and Behavioral Reactions under Extreme Stress Conditions", led by Lt. Asst. Nadежda Slaveeva Vladimirova; National Polar Research Programme 2017–2021 (NPRP), Ministry of Education and Science (2022).
  9. Participation in Project No. 23004, "Antidotal Effect of Intralipid 20% in Acute Fentanyl Intoxications", led by Prof. Dr. Petko Penkov Marinov, MD, funded by the Science Fund of the Medical University “Prof. Dr. Paraskev Stoyanov" – Varna (2023)

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Член на

  1. Bulgarian Pharmaceutical Union
  2. Bulgarian Society for Nutrition and Dietetics
  3. Bulgarian Society of Clinical Toxicology
  4. Bulgarian Society of Pharmacology, Clinical Pharmacology and Therapy​