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Medical University - Varna
Prof. Dr. Paraskev Stoyanov

За нас

Prof. Anton Tonchev MD, PhD, DSc


Катедра: Anatomy and Cell Biology
 УС:
 Е-поща: anton.tonchev@mu-varna.bg
Телефон: 052/ 677 082

 

Биография


Anton B. Tonchev graduated from the Medical University of Varna in 1998 with a Master's degree in Medicine. From 1998 to 2003, he worked at the Department of Neurosurgery, Kanazawa University, Kanazawa, Japan. In 2003, he defended his PhD dissertation on the topic "Quantity and phenotype of proliferating cells in the post-ischemic brain of adult monkeys". Since 2004, he has been an assistant professor at the Department of Forensic Medicine, Deontology and Cell Biology, and since 2008 at the Department of Anatomy, Histology and Embryology at MU-Varna. In 2007, he defended his dissertation for the degree of Doctor of Medical Sciences on the topic "Long-term fate and molecular control of endogenous progenitor cells in the adult primate telencephalon". He obtained a Specialy in Anatomy, histology and cytology in 2008. 
Since 2009, he was promoted Senior Assistant Professor, and since 2010 - Associate Professor at MU-Varna. Since 2013, he has become full Professor at the Department of Anatomy and Cell Biology. In the period 2012 - 2024, he had served as the Head of the Department of Anatomy and Cell Biology. AB Tonchev is the founder of the elective course in "Neurobiology" at MU-Varna. 
Tonchev was a recipient of a Humboldt Scholarship (2009-2011) and a Research Linkage Grant (2014-2017) for the implementation of joint scientific projects with the Max Planck Institute for Biophysical Chemistry, Göttingen, Germany. He has over 100 publications with a total impact factor of over 200 (ORCID: 0000-0003-1536-4352), H-index 34 (GScholar: https://scholar.google.com/citations?user=opCM8mwAAAAJ&hl=en) and more than 100 participations in national and international scientific forums. 
The main scientific direction of Anton B. Tonchev's research are stem cells in the brain, adult neurogenesis and brain regeneration. A. Tonchev is the main organizer of the international conference "Black Sea Neurogenesis": www.blacksea-neuro.org. Tonchev is scientific supervisor or consultant to over 10 PhD students, mainly in the field of neurogenesis. Since 2018 he has been elected as the Director of the Research Institute of MU-Varna.


Публикации

Selected publications:

Tonchev AB, Yamashima T, Zhao L, Okano HJ, Okano H. Proliferation of neural and neuronal progenitors after global brain ischemia in young adult macaque monkeys. Mol Cell Neurosci 2003; 23: 292-301.

Tonchev AB, Yamashima T, Sawamoto K, Okano H. Enhanced proliferation of progenitor cells in the subventricular zone and limited neuronal production in the striatum and neocortex of adult macaque monkeys after global cerebral ischemia. J Neurosci Res 2005; 81: 776-788.

Tonchev AB, Yamashima T. Differential neurogenic potential of progenitor cells in dentate gyrus and CA1 sector of the postischemic adult monkey hippocampus. Exp Neurol 2006; 198: 101-113.

Tuoc TC, Radyushkin K, Tonchev AB, Pinon MC, Ashery-Padan R, Molnar Z, Davidoff MS, Stoykova A. Selective cortical layering abnormalities and behavioral deficits in cortex-specific Pax6 knock-out mice. J Neurosci 2009; 29: 8335-8349.

Tonchev AB. Brain ischemia, neurogenesis, and neurotrophic receptor expression in primates. Archives Italiennes de Biologie 2011; 149: 225-231.

Rosenthal EH, Tonchev AB, Stoykova A, Chowdhury K. Regulation of archicortical arealization by the transcription factor Zbtb20. Hippocampus. 2012;22:2144-56. 

Tonchev AB, Tuoc TC, Rosenthal EH, Studer M, Stoykova A. Mol Brain. 2016;9(1):65. Zbtb20 modulates the sequential generation of neuronal layers in developing cortex. 

Doeppner TR, Herz J, Bähr M, Tonchev AB, Stoykova A. Zbtb20 Regulates Developmental Neurogenesis in the Olfactory Bulb and Gliogenesis After Adult Brain Injury. Mol Neurobiol. 2019 Jan;56(1):567-582. 

Chongtham MC, Wang H, Thaller C, Hsiao NH, Vachkov IH, Pavlov SP, Williamson LH, Yamashima T, Stoykova A, Yan J, Eichele G, Tonchev AB. Transcriptome Response and Spatial Pattern of Gene Expression in the Primate Subventricular Zone Neurogenic Niche After Cerebral Ischemia. Front Cell Dev Biol 2020 Dec 3;8:584314. 

Kerimoglu C, Pham L, Tonchev AB, Sakib MS, Xie Y, Sokpor G, Ulmke PA, Kaurani L, Abbas E, Nguyen H, Rosenbusch J, Michurina A, Capece V, Angelova M, Maricic N, Brand-Saberi B, Esgleas M, Albert M, Minkov R, Kovachev E, Teichmann U, Seong RH, Huttner WB, Nguyen HP, Stoykova A, Staiger JF, Fischer A, Tuoc T. H3 acetylation selectively promotes basal progenitor proliferation and neocortex expansion. Sci Adv 2021;7(38):eabc6792. 

Roeder SS, Burkardt P, Rost F, Rode J, Brusch L, Coras R, Englund E, Håkansson K, Possnert G, Salehpour M, Primetzhofer D, Csiba L, Molnár S, Méhes G, Tonchev AB, Schwab S, Bergmann O, Huttner HB. Evidence for postnatal neurogenesis in the human amygdala. Commun Biol 2022;5(1):366. 

Stoyanov DS, Ivanov MN, Yamashima T, Tonchev AB. Expression of Transcription Factor ZBTB20 in the Adult Primate Neurogenic Niche under Physiological Conditions or after Ischemia. Genes (Basel) 2022;13(9):1559. 

Roeder SS, Bonnin EA, Wu TD, Guerquin-Kern JL, Jabari S, Brandner S, Eyüpoglu IY, Gollwitzer S, Hamer HM, Gerner ST, Doeppner TR, Rummel C, Englund E, Heimke-Brinck R, Borst T, Daniel C, Amann K, Schlötzer-Schrehardt U, Tonchev AB, Roessler K, Schwab S, Bergmann O, Rizzoli SO, Huttner HB. Tracking cell turnover in human brain using 15N-thymidine imaging mass spectrometry. Front Neurosci 2023 Oct 5;17:1274607.

​Marinova D, Ivanov MN, Yamashima T, Tonchev AB. Quantity, distribution and phenotype of newly generated cells in the intact spinal cord of adult macaque monkeys. Heliyon 2024 Mar 29;10(7):e28856. doi: 10.1016/j.heliyon.2024.e28856. 

Ivanov MN, Stoyanov DS, Veleva LV, Mladenov AM, Pavlov SP, Yamashima T, Tonchev AB. TNC and GJA1 Are Putative Progenitor Markers That Are Localized in the Perivascular Adventitia of the Adult Monkey Brain Subventricular Niche. Int J Mol Sci 2025 Feb 7;26(4):1397. doi: 10.3390/ijms26041397. 

Pavlov P, Kontny A, Wagner N, Kolev N, Zlatarov A, Kalinov T, Tonchev AB. 3D visualization of human colon tissue using a modified CUBIC-based tissue-clearing technique. J Biol Methods 2025 Feb 4;12(1):e99010052. doi: 10.14440/jbm.2025.0101.​​​ 


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