Education:
Master in Molecular Biology with specialization in Biochemistry – Sofia University “St. Kliment Ohridski", 1985;
Master in Health Management) - Medical University of Varna, 2013.
Acquired scientific degrees and academic positions held:
Educational and scientific degree “Doctor" in scientific specialty “Cell Biology" and “Plant Physiology" - Faculty of Biology, Moscow State University “M. V. Lomonosov", Moscow, Russia, 1990;
Academic title “Associate Professor" – 2007;
Academic title "Professor" – 2013;
Scientific degree "Doctor of Science" in the field of higher education 4. Natural Sciences, Mathematics and Informatics, Professional field 4.3 Biological Sciences - Medical University - Varna, 2013.
Areas of professional interest:
The main scientific developments are in the field of oxidative status in various physiological and pathological conditions and antioxidant protection, nutrigenomics and metabolic adaptation, biochemistry of nutrition and related socially significant diseases, molecular biology; Health management; Research management; Modern approaches in biochemistry education.
Membership in scientific organizations:
NuGO - European Association for Nutrigenomics, Coordinator for Bulgaria, since 2007 - Member of the Board (2016-2024);
ABCB - Association of Biochemistry Departments in Bulgaria, since 2010, Secretary;
SUB - Section of Biochemistry, Biophysics and Molecular Biology (member of FEBS) at the Union of Scientists in Bulgaria, since 2001, (Union of Scientists Varna, since 1992);
Member of the Supreme Council of Pharmacy at the Ministry of Health, since 2015
Specializations and work abroad:
Specialization in Biochemistry under Regulation 34/2006 on the acquisition of a specialty in the healthcare system – 2008
Erasmus+: Invited lecturer (“Molecular nutrition and nutrigenomics"), Faculty of Pharmacy of Collegium Medicum at Nicolaus Copernicus University, Toruń, Poland, under Contract No. 2021-I-BG01-KA13I-HED-000009090, 2023
Erasmus+: Training to improve cooperation, sharing experience, transfer of information, knowledge and competences, Medical University – Silesia, Poland, 2016
Erasmus+: Training to improve cooperation, sharing experience, transfer of information, knowledge and competences, Medical University – Gdańsk, Poland, 2015;
Specialization at the Norwegian School of Sports Sciences in Oslo, Norway in “Management of Research and activity" with a scholarship under the European Economic Area Financial Mechanism Program, led by Prof. J. Jensen, 2010;
NuGO (European Nutrigenomics Association) scholarship for the development of a joint project for the development of the Nutrigenomics Center at MU Varna in collaboration with the University of Wageningen, Netherlands, 2008;
International Institute of Education (IIE), USA: scholarship for participation in the International Meeting of ACA (Association for Academic Cooperation) “International Campus" in Budapest, Hungary, 2004;
Summer School on Free Radicals (SFRR and IUBMB), Istanbul, Turkey scholarship from IUBMB, 2002;
Visiting Researcher at the Department of Chemistry and Biochemistry, University of Massachusetts, Dartmouth, USA, scholarship under the Scientific Exchange Program of the University of Massachusetts, Dartmouth, USA (two-year specialization in molecular biology), Associate Professor B. Singh, 1999 –2001;Erasmus +: 17–20 October 2016 lecturer (Nutrigenomics, 8 hours) at the Medical University of Silesia, Poland;
Specialization in Biochemistry and Molecular Biology at the Center for Genetics, Swedish University of Agricultural Sciences, Uppsala, Sweden, Visiting Research Fellow, Swedish Research Council Fellowship, L-R Prof. J. Meyer, 1998-1999;
Short-term specialization at the Department of Biochemistry, University of Dundee, UK; “Development and implementation of new approaches in the teaching of biochemistry to medical students", British Council Fellowship, L-R Prof. D. Stansfield, 1998
Open Society Fellowship for participation in the International Congress “Stress of Life", Budapest, Hungary
Scientific and research activity:
Awards for high scientific achievements:
Winner of the award of the Union of Scientists - Varna in the competition for high achievements of Varna scientists - 2023
Winner of the Award of the Dean of the Faculty of Pharmacy named after "Prof. Dr. Delcho Zhelyazkov" for overall contribution to the development and raising the prestige of the Faculty of Pharmacy of the Medical University "Prof. Dr. Paraskev Stoyanov", Varna, 2023
Winner of the "Honorary Badge with a Blue Ribbon" for merits in scientific and research activity and affirmation of the academic authority of the Medical University - Varna before the Bulgarian and international academic community, 2012
Areas of scientific and research activity:
Research on oxidative status and antioxidant protection, nutritional and metabolic adaptation, biochemistry of nutrition and related socially significant diseases, with over 150 scientific publications in the field. She is the supervisor of a large number of successfully defended PhD students and is the coordinator of dozens of scientific projects related to nutrigenomics and clinical biochemistry. Her international research activity contributes to the creation of a strong scientific research unit and group in nutrigenomics at the Medical University of Varna.
Participation in contracts, projects, and programs
BG-RRP-2.004-0009-C02. “Medical University - Varna: Enhancing Translational Achievements in Medicine" (MUVE-TEAM), 2022-2026, European Union, National Recovery and Resilience Plan of Bulgaria under the procedure for “Establishing a Network of Research Universities in Bulgaria", Chairman of the Management Board;
Contract FN 30/26.05.2022, SD 105/14.07.2022, No. 21015 “Molecular mechanisms of action of cytodeox: new data in support of neuroprotective and antioxidant effects", funded by the Science Fund at the Medical University of Varna, head Assoc. Prof. M. Nashar;
Project 3.4.3 “Development of combined products of natural origin with immunomodulatory, antioxidant and vascular protective effects", funded under the project “Medical University - Varna: Enhancing translational achievements in medicine (MUVE-TEAM)" BG-RRP-2.004-0009-C02. 27.03.2024 – 27.09.2025, head: Assoc. Prof. O. Tasinov;
Project 3.4.2 “Panel of genetic biomarkers in colorectal carcinoma", funded under the project “Medical University - Varna: Enhancing translational achievements in medicine (MUVE-TEAM)" BG-RRP-2.004-0009-C02. 27.03.2024 – 27.09.2025, head: Prof. Y. Kiselova-Kaneva;
PR No. 18036, Science Fund at MU - Varna, "Identification of biomarkers in saliva for assessing the risk profile of gingival health in childhood", project manager;
PR Contract No. KP-06-OPR03/18, 19.02.2018. "Algotoxins - a new risk factor for the quality of life and health of people in Bulgaria", under the Scientific Research Fund of the Ministry of Education and Science, competition for funding fundamental scientific research on societal challenges - 2018, 2018-2020, manager Prof. Hr. Gagov, Sofia University;
PR No. 18027 – "Lipid nanoparticles - a modern technological approach for incorporating hyperforin with improved chemical stability into dosage forms for topical administration and accelerated wound healing", 2018-2020, Assoc. Prof. V. Andonova;
DN13/9 of 15.12.2017, Competition funded by the FNI-MES, Topic: "Cyanoprokaryotes - a new potential risk factor for malignant diseases in Bulgaria?", Head of the project: Prof. Dr. Maya Stoyneva-Gertner;
Contract DNTS/France 01/11 of 09.05.2017, Competition for projects under bilateral cooperation programs 2016 Bulgaria - University Agency of Francophonie, Topic: "Autoimmune response against plasma proteins of the innate immune system", Head of the project: Assoc. Prof. M. Radanova;
PR №17002, Science Fund – 2017 of MU-Varna, Topic: “Vitamin K-dependent GLA-proteins – new biomarkers for cardiovascular calcification", supervisor Prof. B. Kalcheva;
PR №17015, Science Fund – 2017 of MU-Varna, Topic: “Study of the effects of sulfur-containing mineral waters on sulfur metabolism in humans", supervisor Assoc. Prof. M. Nashar;
BG05M2OP001-2.002-0001 “Student Internships – Phase 1" of MES, funded by OP NOIR 2014-2020 and co-funded by the EU, Academic Mentor;
Contract DN01/12 of 16.12.2016, Competition for funding of fundamental scientific research by FNI- MEYS 2016, Topic: "Study of the molecular mechanisms of action of sulfur-containing mineral waters from the Varna basin on human metabolism with a view to their use as a medicinal and drinking agent", supervisor;
Contract No. 16020, Medical Science Fund - 2016 of MU-Varna, Topic: "Study of the gene expression of some poorly studied proteins and micro RNAs with a view to their application as molecular markers in patients with colorectal carcinoma", supervisor, senior asst. O. Tasinov;
Project No. 14013, Medical Science Fund – 2015, Topic: “Investigating the therapeutic potential of black mulberry wood as a resource for the pharmaceutical industry", head;
КВВЕ.2011.2.2-02, Grant agreement no: 289511 “NutriTech - Application of new technologies and methods in nutrition research – the example of phenotypic flexibility", funded by the European Commission, 2012-2016, Project manager from the Bulgarian side; project manager Ben van Ommen, Netherlands;
BG051PO001-3.1.07-0046, OP “Human Resources Development" – 2012 of the EU, Topic: “Updating and testing the curricula and programs of the Faculty of Pharmacy at the Medical University - Varna in accordance with the needs of the pharmaceutical business and the requirements of the labor market", head Prof. A. Kerekovska;
BG051PO001-3.1.09-0013, OP "Human Resources Development" - 2012 of the EU, Topic: "Creation of a modern system for career growth of teachers at the Medical University "Prof. Dr. Paraskev Stoyanov" - Varna", supervisor Prof. Dr. Kr. Ivanov;
DKOF7RP02/13, Action No. BM0602, National co-financing under COST, Topic: "Adipose Tissue: A Key Target for Prevention of the Metabolic Syndrome", leader;
VU-L-320/07g., MES, Scientific Research Fund, in collaboration with the Institute of Organic Chemistry with the Laboratory of Phytochemistry at the Bulgarian Academy of Sciences and Obesity Biology Unit, School of Clinical Sciences, University of Liverpool, United Kingdom; Topic: "Study of the antioxidant, anti-inflammatory and antidiabetic activity of Bulgarian herbs as a potential resource for nutraceuticals", leader;
2009-2010, Funded by the "Medical Science Fund" at the Medical University - Varna, Topic: "Study of the relationship between the presence of some polymorphisms in the FTO, ADIPO Q and ADIPO R2 genes and the risk of the manifestation of high-grade obesity and metabolic syndrome in a representative sample of the Bulgarian population". Joint scientific project with the Department of Internal Medicine, Clinic of Pediatrics and the Department of General Medicine at the Medical University of Varna, head;
DO 02-17/13.12.2008, MES, Scientific Research Fund, No Rila-4/507, Joint scientific project with the French National Reference Laboratory for Analysis of Complement Proteins, Topic: "Relationship of Mutations and Polymorphisms in the Genes for the C1q Component of the Complement System with Systemic Lupus Erythematosus", head;
COST Action BM0602 “Adipose Tissue: A Key Target for Prevention of the Metabolic Syndrome". Funded by the EC. 2007-2011, MC member (Bulgaria);
AGREEMENT NUMBER- 2007 328 “In Form - Campaign against obesity in children and adolescents", 2012-2016 funded by the European Commission, Executive Agency for Health and Consumers (EAHC); Coordinator: SANICADEMIA (lnternationale Forthildungsakademie fiir Gesundheitsherufe EWIV-EEIG); Partner: Nutrigenomics Center at Medical University Varna, Partner coordinator;
Project BG051PO001-3.1.09-0013 "Creating a modern system for career growth of teachers at the Medical University "Prof. Dr. Paraskev Stoyanov" - Varna, 2013 -2014, funded by the European Social Fund under the Operational Program "Human Resources Development". Project manager: Prof. T. Kostadinova.
Scientific publications
Open access
Over 100 scientific papers in the field of metabolic changes in various physiological and pathological conditions, antioxidant protection, nutrigenomics and metabolic adaptation, biochemistry of nutrition and related socially significant diseases published; over 80 participations in scientific forums; 6 biochemistry study books for medical students issued.
Lecture courses in "Biochemistry" and in "Molecular Biology in Medicine" for the "Medicine" programs in Bulgarian and in English, new coursed in ""Methodology of Research" and "Scientific Projects and Programmes" for the "Technology Transfer and Innovations in Pharmacy" programme at MUV; courses in "Biochemistry and pathobiochemistry" for the "Assistant Pharmacist" and "Medical Laboratory Technician" at the Medical College of MUV.
Selected publications (https://orcid.org/0000-0002-4502-081X):
Fiamoncini J, Donado-Pestana CM, Duarte GBS, Rundle M, Thomas EL, Kiselova-Kaneva Y, Gundersen TE, Bunzel D, Trezzi JP, Kulling SE, Hiller K, Sonntag D, Ivanova D, Brennan L, Wopereis S, van Ommen B, Frost G, Bell J, Drevon CA, Daniel H. Plasma Metabolic Signatures of Healthy Overweight Subjects Challenged With an Oral Glucose Tolerance Test. Front Nutr. 2022 Jun 14; 9:898782. doi: 10.3389/fnut.2022.898782. PMID: 35774538; PMCID: PMC9237474.
Tasinov, O.; Dincheva, I.; Badjakov, I.; Kiselova-Kaneva, Y.; Galunska, B.; Nogueiras, R.; Ivanova, D. Phytochemical Composition, Anti-Inflammatory and ER Stress-Reducing Potential of Sambucus ebulus L. Fruit Extract. Plants 2021, 10, 2446. https://doi.org/10.3390/plants10112446
Tasinov O, Kiselova-Kaneva Y, Ivanova D, Pasheva M, Vankova D, Ivanova D., Ferrum phosphoricum D12 Treatment Affects J774A.1 Cell Proliferation, Transcription Levels of Iron Metabolism, Antioxidant Defense, and Inflammation-related Genes. Homeopathy 2022; 111(02): 113-120; DOI: 10.1055/s-0041-1731312
Yaneva G, Ivanov D, Ivanova D. Ozone features in the context of advancing COVID-19 pandemic. J of IMAB. 2021 Oct-Dec;27(4):3999-4003. DOI: 10.5272/jimab.2021274.3999
Nazifova-Tasinova NF, Atanasov AA, Pasheva MG, Yotov YT, Gerova DI, Vankova DG, Todorova MN, Ivanova DG, Kiselova-Kaneva YD & Galunska BT (2020) Circulating uncarboxylated matrix Gla protein in patients with atrial fibrillation or heart failure with preserved ejection fraction, Archives of Physiology and Biochemistry, DOI: 10.1080/13813455.2020.1786130
Olczyk P, Komosinska-Vassev K, Krzyminiewski R, Kasperczyk J, Ramos P, Dobosz B, Batoryna O, Stojko J, Stojko M, Ivanova D, Olczyk K, Pilawa B, "The Estimation of Blood Paramagnetic Center Changes during Burns Management with Biodegradable Propolis-Nanofiber Dressing", Oxidative Medicine and Cellular Longevity, vol. 2020, Article ID 3675603, 9 pages, 2020. https://doi.org/10.1155/2020/3675603
Angelova S., Salim A., Kiselova-Kaneva Y., Ivanova D., Peev S. (2019). Association of mRNA Levels of IL6, MMP-8, GSS in Saliva and Pyelonephritis in Children. Molecules 2020, 25 (1), 85.
Jura-Półtorak A., Olczyk P., Chałas-Lipka A., Komosińska-Vassev K., Kuźnik-Trocha K., Winsz-Szczotka K., Ivanova D., Kiselova-Kaneva Y., Krysik K., Telega A. & Olczyk K. (2019). Urinary sulphated glycosaminoglycans excretion in obese patients with type 2 diabetes mellitus treated with metformin. Archives in Physiology and Biochemistry, 1-7.
Vankova D., Pasheva M., Kiselova-Kaneva Y., Ivanov D., Ivanova D. (2019). Mechanisms of cyanotoxin toxicity – cancerogenicity and anticancer potential. Medical Toxicology, ISBN 978-1-83880-278-3, Publisher: InTechOpen (chapter).
Sokrateva T., Roussev B., Nashar M., Kiselova-Kaneva Y., Mihaylova G., Todorova M., Pasheva M., Tasinov O., Nazifova-Tasinova N., Vanova D., Ivanova D.P., Radanova M., Galunska B., Vlaykova T., Ivanova D.G. (2019). Effects of sulfur-containing mineral water intake on oxidative status and markers for inflammation in healthy subjects. Archives in Physiology and Biochemistry, DOI: 10.1080/13813455.2019.1638416.
Wilczyński S., Koprowski R., Stolecka-Warzecha A., Duda P., Deda A., Ivanova D., Kiselova-Kaneva Y., Błońska-Fajfrowska B. (2019). The use of microtomographic imaging in the identification of counterfeit medicines. Talanta, V195, 870-875.
Nashar M., Kiselova-Kaneva Y., Ivanova D. (2019). Antidiabetic potential of plants used in Bulgarian folk medicine and traditional diet. Nutrition in Health and Disease, ISBN 978-1-78984-008-7. Publisher: IntechOpen (chapter) DOI: 10.5772/intechopen.85445.
Todorova M., Kiselova-Kaneva Y., Potoroko I, Kalinina I, Galunska B. (2019). Antioxidant activity of taxifolin derived from larch: synergistic studies. Bulgarian Chemical Communications, V 51 (A): 172-176.
Roussev B., Sokrateva T., Nashar M., Radanova M., Komosinska-Vassev K., Olczyk P., Potoroko I Y, Ivanova D. (2019). Effects of sulfur-containing mineral water on the renal function: a human interventional study. Compt. Rend. Acad. Bulg. Sci. T 72, No 11, DOI:10.7546/CRABS.2019.11.16
Komosinska-Vassev K., Olczyk P., Kasperczyk J., Pilawa B., Krzyminiewski R., Dobosz B., Ramos P., Stojko J., Stojko M., Ivanova D., Olczyk K. (2019). EPR spectroscopic examination of different types of paramagnetic centers in the blood in the course of burn healing. Oxidative Medicine and Cellular Longevity. DOI: 10.1155/2019/7506274.
Kalinina I., Potoroko I., Fatkullin R., Ivanova D., Kaneva-Kiselova Y., Sonawane S. (2019). Improvement in biological activity of dihydroquerecetin by means of ultrasound micronization, Технология и товароведение инновационных пищевых продуктов 143 (144), 291-296.
Fiamoncini J, Rundle M, Gibbons H, Thomas E.L, Geillinger-Kästle K, Bunzel D, Trezzi J, Kiselova-Kaneva Y Wopereis S, Wahrheit J, Kulling SE, Hiller K, Sonntag D, Ivanova D, van Ommen B, Frost G, Brennan L, Bell J, Daniel H. (2018). Plasma metabolome analysis identifies distinct human metabotypes in the postprandial state with different susceptibility
Synowiec-Wojtarowicz A, Kiselova Y, Ivanov D, Ivanova D, Bialik W, Kimsa-Dudek M, Pawłowska–Góral K. 2018. Effects of polyphenol supplementation to in vitro antioxidant potential of citrus juices. Scripta Scientifica Pharmaceutica, 5 (1), 28-32.
Pasheva M, Nashar M, Ivanov D, Ivanova D. (2018). Traditional usage of heartwood from different arboreal species in inland and coastal regions of Bulgaria. Acta zool. bulg., Suppl. 11: 99-104.
Text books for students:
Ivanova D, Galunska B, Nashar M, Radanova M, Kiselova-Kaneva Y. 2016. Tasks and practical exercises in biochemistry. A Guide for Medical Students. Second revised and supplemented edition, "Helix Press" - Varna, p. 180. ISBN 978-619-7147-14-8.
Ivanova D, Kiselova-Kaneva Y, Galunska B, Nashar M, Vankova D. 2015. A handbook of biochemistry. Review study questions and laboratory manuals - a clinical approach. Publ. Ris Varna Ltd., p. 174, ISBN 978-954-8165-18-1.
Galunska B., Ivanova D., Vankova D., Tasinov O. (2012). A Guide to Biochemistry for Dental Students. Ed. Medical University "Prof. Dr. Paraskev Stoyanov", Varna, p. 128. ISBN 978-954-9685-67-1.
Ivanova D., Galunska B., Nazifova N., Kiselova-Keneva Y. Tasks and practical exercises in biochemistry. A Guide for Pharmacy Students. (2012). Ed. Medical University "Prof. Dr. Paraskev Stoyanov" - Varna, p. - 164. ISBN 978-954-9685-74-9.
Ivanova D., Galunska B., Nashar M., Pavlov D. (2011). PROBLEMS AND PRACTICAL EXERCISES IN BIOCHEMISTRY, A Guide for Medical Students. Ed. Medical University "Prof. Dr. P. Stoyanov" Varna, p.– 164. ISBN 978-954-9685-59-6.
Ivanova D. (2003). A Basic Course in Molecular Biology in Medicine, A Guide for Medical Students. Ed. Medical University "Prof. Dr. P. Stoyanov" Varna, village-111. ISBN 954-9685-19-5.
