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Medical University - Varna
Prof. Dr. Paraskev Stoyanov
Translation BG

За нас

Chief Assistant Professor Ayshe Seyhan Salim Phd


Катедра: Department of Biochemistry, Molecular Medicine and Nutrigenomics
 УС:
 Е-поща: Ayshe.Salim@mu-varna.bg
Телефон: 052/677-050

 

Биография

Education:

PhD in "Microbiology" (2014-2017), Plovdiv University "Paisii Hilendarski",Faculty of Biology, Department of Biochemistry and Microbiolgy, Plovdiv

Master in "Biopharmaceutical biochemistry" (2011-2013), Plovdiv University "Paisii Hilendarski",Faculty of Biology, Plovdiv

Bachelor in "Molecular biology" (2007-2011), Plovdiv University "Paisii Hilendarski",Faculty of Biology, Plovdiv

Academic positions

Chief Assist. Prof. at Medical University "Prof. D-r. Paraskev Stoyanov " – Varna, Faculty of Pharmacy, Department of Biochemistry , Molecular Medicine and Nutrigenomics, Varna (29.11.2019 - present)

 

Assist. Prof. at Medical University "Prof. D-r. Paraskev Stoyanov " – Varna, Faculty of Pharmacy, Department of Biochemistry , Molecular Medicine and Nutrigenomics, Varna (12.03.2018 – 27.11.2019)

 

Part-time Assistant Professor at Plovdiv University "Paisii Hilendarski", Faculty of Biology, Department of Biochemistry and Microbiology (2012-2013)

Main research area and subareas

Biochemistry, Molecular biology, Nutrigenomics, Enzymology, Functional foods

Membership in scientific societies

Member of the Union of Scientist-Varna

Member of the European Nutrigenomics Organisation (NuGO)

Member of the Association of Biochemical Departments in Bulgaria

 Specializations abroad and international collaborations

  1. "Fourth European Summer school on Nutrigenomics", European Nutrigenomics Organisation (NuGO), virtual edition, June 21-25, 2021.
  2. Online seminar "Gene expression regulation: a computational point of view", National Program "European Research Networks", November 18-19, 2021.
  3. "SPSS Applied Biostatistics Course", VII. International Congress of Molecular Medicine, Istanbul, Turkey, September 5, 2019.
  4. Genome Architecture and Dynamics International Workshop and Summer School, Varna, Bulgaria, July 12 – July 19, 2019.
  5. Polymerase Chain Reaction Workshop, International Molecular Medicine Symposium by the Bosphorus, Istanbul, Turkey, May 16, 2019.
  6. Cell Culturing Workshop, International Molecular Medicine Symposium by the Bosphorus, Istanbul, Turkey, May 16, 2019.
  7. European program IPARAF (Intensive Programme for Advanced Residue Analysis in Food) - an intensive course in analytical chemistry techniques applied in the analysis of food at ONIRIS- Nantes Atlantic National College of Veterinary Medicine, Food Science and Engineering, Nantes, France (2012)

 

 Participation in projects

  1. "Molecular Mechanisms of Action of Cytodeоx: New Data in Support of Neuroprotective and Antioxidant Effects", funded by the "Science" Fund at the Medical University of Varna, Project leader Assoc. Prof. Milka Nashar, PhD, implementation period 2022-2025
  2. "Relationship between vitamin D status and sperm quality as a factor in assessing of male reproductive health", funded by "Bulgarian National Scientific Fund" Competition for financial support for projects of junior basic researchers and postdocs – 2020, 2020 with the term 2020 - 2022. Supervisor - Chief Assistant Bogdan Roussev
  3. "Identification of biomarkers in saliva for risk profile evaluation of gingival health in childhood", Project № 18036, Science Foundation, MU-Varna, 2018-2022, project coordinator: Prof. Diana Ivanova.
  4. "Identification of next-generation biomarkers for diagnostic evaluation of activity and follow-up of patients with systemic lupus erythematosus", Project № 18010, Foundation, MU-Varna, 2018-2020, project coordinator: Associate Professor Mariq Radanova.
  5. "Expression profiling of non-coding RNAs in colorectal cancer", Contract № КП-06-Н23/6, 18.12.2018, BNSF, 2018-2021, project coordinator: Associate Professor Mariq Radanova
  6. "Investigation of the adaptogenic potential of Sambucus ebulus fruits for their use as a functional food", Contract № КП-06-ОПР03/13, 18.12.2018, BNSF, 2018-2021, project coordinator:  Associate Professor: Yoana Kiselova-Kuneva.
  1. "Investigation of the functional properties of Glycosyltransferases produced by lactic acid bacteria and their application for controlled synthesis of oligosaccharides with increased prebiotic properties", Contract № ДМ01/7, 2016, BNSF, 2016-2018, project coordinator:  Chief Assistant Professor Veselin Bivolarski.
  2. "Enzymatic modification of plant polysaccharides", Project № НИ 13 ФК 013, 2013-2014, Science Foundation, Plovdiv University 2013-2014, project coordinator: Associate Professor Vanya Markova Naydenovva-Marinova.
  3. "Investigation of the mechanism of action of xylo-oligosaccharides and β-glucans in relation to increase their prebiotic potential", Contract № ДФНИ-Б01/7, BNSF, 2012-2014, project coordinator: Associate Professor Balik Djambaov.

 

 

Scientific publications

1.     Sirma Angelova, Ayshe Salim, Bogdan Roussev, Yoana Kiselova-Kaneva, Diana Ivanova, Stefan Peev. Association of the Salivary sIgA and Dextran with Clinical Parameters of Plaque-induced Gingivitis in Children. Journal of IMAB, Supplement Journal of IMAB, 2021, 33-36.

2.     Radanova M, Mihaylova G, Tasinov O, Ivanova DP, Stoyanov GS, Nazifova-Tasinova N, Manev R, Salim A, Nikolova M, Ivanova DG, Conev N, Mihaylova Z, Donev I. New Circulating Circular RNAs with Diagnostic and Prognostic Potential in Advanced Colorectal Cancer. Int J Mol Sci. 2021 Dec 10;22(24):13283. doi: 10.3390/ijms222413283. PMID: 34948079; PMCID: PMC8706615.

3.     Sirma Angelova, Ayshe Salim, Yoana Kiselova-Kaneva, Diana Ivanova, Radosveta Andreeva-Borisova, Stefan Peev. The role and significance of some salivary amino acids in periodontal diseases, including plaque-induced gingivitis—a literature review. Scripta Scientifica Medicinae Dentalis, 2021, 7(2), 7-17.

4.     Veselin Bivolarski, Ilia Iliev, Iskra Ivanova, Mariana Nikolova, Ayshe Salim, Galya Mihaylova, Tonka Vasileva (2021). Characterization of structure/prebiotic potential correlation of glucans and oligosaccharides synthetized by glucansucrases from fructophilic lactic acid bacteria from honey bee Apis mellifera. Biotechnology & Biotechnological Equipment 35 (1), 674-687. https://doi.org/10.1080/13102818.2021.1911683.

5.     Angelova S., Salim A., Kiselova-Kaneva Y., Ivanova D. and Peev S. 2019. Association of mRNA Levels of IL6, MMP-8, GSS in Saliva and Pyelonephritis in Children. Molecules 2020, 25, 85; doi:10.3390/molecules25010085

6.     Sokrateva T., Nashar M., Salim A., Vlaykova T., Ivanova D. 2019. Health effects of sulfurous mineral water may vary depending on lifestyle. J of IMAB. 2019 Oct-Dec;25(4)

7.     A.S. Salim, V. P. Bivolarski, T. A. Vasileva, Ilia N. Iliev* (2017) Enzymatic synthesis of fructo-oligosaccharides by recombinant levansucrase from Leuconostoc mesenteroides Lm17. Bulgarian Chemical Communications, Volume 49, Special Edition D, pp. 259 – 264;

8.     Ilia Iliev, Tonka Vasileva, Veselin Bivolarski, Ayshe Salim, Sandrine Morel,Philippe Rabier & Valérie Gabriel (2018) Optimization of the expression of levansucrase L17 in recombinant E. Coli. Biotechnology & Biotechnological Equipment DOI: 10.1080/13102818.2018.1431056;

9.     Tonka Vasileva, Veselin Bivolarski, Galya Michailova, Ayshe Salim, Yavor Rabadjiev,Iskra Ivanova and Ilia Iliev (2016) Glucansucrases produced by fructophilic lactic acid bacteria Lactobacillus kunkeei H3 and H25 isolated from honeybees. J. Basic Microbiol. 56, 1–10;

10.  Tonka Vasileva, Veselin Bivolarski, Ayshe Salim, Petko Bozov, Ilia Iliev (2014) Influence of silymarin on glycosyltransferases from Leuconostoc mesenteroides URE 13 and Lm 28 strains. Comptes rendus de l'Académie bulgare des sciences: sciences mathématiques et naturelles 67(10):1377-1382;

11.  Petko I. Bozov, Rumen D. Mladenov, Ivanka Dimitrova, Veselin P. Bivolarski, Galya M. Mihaylova, Ayshe S. Salim, Tonka A. Vasileva (2014) Influence of extracts from Mentha aquatica L. and Mentha longifolia L. on the activity of glycosyltransferases from Leuconostoc mesenteroides strains. Journal of BioScience & Biotechnology Special Edition, p61-66. 6p.

 

 


Публикации

Publications


  1. Angelova S., Salim A., Kiselova-Kaneva Y., Ivanova D. and Peev S. 2019. Association of mRNA Levels of IL6, MMP-8, GSS in Saliva and Pyelonephritis in Children. Molecules 2020, 25, 85; doi:10.3390/molecules25010085
  2. Sokrateva T., Nashar M., Salim A., Vlaykova T., Ivanova D. 2019. Health effects of sulfurous mineral water may vary depending on lifestyle. J of IMAB. 2019 Oct-Dec;25(4)
  3. A.S. Salim, V. P. Bivolarski, T. A. Vasileva, Ilia N. Iliev* (2017) Enzymatic synthesis of fructo-oligosaccharides by recombinant levansucrase from Leuconostoc mesenteroides Lm17. Bulgarian Chemical Communications, Volume 49, Special Edition D, pp. 259 – 264;
  4. Ilia Iliev, Tonka Vasileva, Veselin Bivolarski, Ayshe Salim, Sandrine Morel,Philippe Rabier & Valérie Gabriel (2018) Optimization of the expression of levansucrase L17 in recombinant E. Coli. Biotechnology & Biotechnological Equipment DOI: 10.1080/13102818.2018.1431056;
  5. Tonka Vasileva, Veselin Bivolarski, Galya Michailova, Ayshe Salim, Yavor Rabadjiev,Iskra Ivanova and Ilia Iliev (2016) Glucansucrases produced by fructophilic lactic acid bacteria Lactobacillus kunkeei H3 and H25 isolated from honeybees. J. Basic Microbiol. 56, 1–10;
  6. Tonka Vasileva, Veselin Bivolarski, Ayshe Salim, Petko Bozov, Ilia Iliev (2014) Influence of silymarin on glycosyltransferases from Leuconostoc mesenteroides URE 13 and Lm 28 strains. Comptes rendus de l'Académie bulgare des sciences: sciences mathématiques et naturelles 67(10):1377-1382;
  7. Petko I. Bozov, Rumen D. Mladenov, Ivanka Dimitrova, Veselin P. Bivolarski, Galya M. Mihaylova, Ayshe S. Salim, Tonka A. Vasileva (2014) Influence of extracts from Mentha aquatica L. and Mentha longifolia L. on the activity of glycosyltransferases from Leuconostoc mesenteroides strains. Journal of BioScience & Biotechnology Special Edition, p61-66. 6p.

 


More:

  1. Sirma Todorova Angelova, Ayshe Seyhan Salim. The Role of Salivary Carbonic Anhydrase VI for Caries Risk Evaluation in Children with Pyelonephritis (постер), VII International Congress of Molecular Medicine, September 5 - 7, 2019, Istanbul, Turkey.
  1.  Salim A., Vasileva T., Bivolarski V., Iliev I. Optimization of transfructosylation reaction for production of fructooligosaccharides catalyzed by recombinant levansucrase from Leuconostoc mesenteroides Lm 17 (постер), 5th International Conference on Novel Enzymes - 11–14 October 2016, Groningen, The Netherlands.
  2. Vasileva T., Bivolarski V., Salim A., Bozov P., Iliev I. Inhibitory effect of substances isolated from Bulgarian herbs on glycosyltransferases from Leuconostoc mesenteroides strains (постер), 4th International Conference on Novel Enzymes - 14 – 17 October 2014, Gent, Belgium.
  3. Bozov P, Mladenov R, Dimitrova I, Bivolarski V, Mihaylova G, Salim A, Vasileva T. Influence of extracts from Mentha aquatica L. and Mentha longifolia L. on the activity of glycosyltransferases from Leuconostoc mesenteroides strains (постер), 3rd Balkan Scientific Conference on Biology - May 30th – June 1st, 2014, Plovdiv, Bulgaria.
  4.  Vasileva T., Iliev I., Bivolarski V., Mihaylova G., Salim A., Bozov P. Study of the Inhibitory effect of propolis extracts on the activity of  glycostltransferases from Leuconostoc mesenteroides Lm28 and Leuconosctoc mesenteroides Lm17 strains (постер), 3rdBalkan Scientific Conference on Biology - May 30th – June 1st, 2014, Plovdiv, Bulgaria.

Участие в национални научни форуми:

  1. Salim A., Bivolarski V., Vasileva T., Iliev I. Optimization of enzymatic synthesis of fructooligosaccharides by levansucrase from Leuconostoc mesenteroides Lm 17(доклад); Salim A., Vasilva T., Bivolarski V., Rabadjiev Y., Ivanova I., Iliev I., Production of glycosyltransferases by fructophilic lactic acid bacteria isolated from honeybees 


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